@article { author = {Baghernejad, Bita and Hojjatitaromsari, Seyedeh Mozhgan}, title = {Preparation of Polyhydroquinolines Using Nano Cerium (IV) Oxide/Zinc Oxide as a Catalyst}, journal = {Journal of Applied Organometallic Chemistry}, volume = {2}, number = {2}, pages = {74-80}, year = {2022}, publisher = {Sami Publishing Company}, issn = {2783-3623}, eissn = {2783-1272}, doi = {10.22034/jaoc.2022.340645.1054}, abstract = {Polyhydroquinolines are crucial compounds with a very wide range of biological functions such as vasodilation, anti-atherosclerosis, liver protection, and anti-diabetic. It is also used in the preparation of drugs such as nifedipine, nicardipine and Lacidipine. The common method of synthesis of polyhydroquinolines is one-step condensation reaction of Dimedone, aldehydes with ethyl acetate and ammonia in the presence of various catalysts such as MCM-41, molecular iodine, bread yeast, etc. Most of these methods have disadvantages such as low gain, high reaction temperature, long time. In this research, cerium oxide / zinc oxide nanoparticles have been reported as a very effective and economical catalyst for the four-component and one-pot reactions of polyhydroquinolines using the reaction of Dimedone, Aryl halide, ethyl acetoacetate and ammonium acetate.}, keywords = {Polyhydroquinolines,Cerium oxide/Zinc oxide,multi component reaction,one-pot condensation reaction}, url = {https://jaoc.samipubco.com/article_153723.html}, eprint = {https://jaoc.samipubco.com/article_153723_302c1259abbfdefc5a4b4a9ef93df393.pdf} }