%0 Journal Article %T Bi(OTf)3 as a Highly Potent Catalyst for the Synthesis of Mannich Bases under Milder Conditions %J Journal of Applied Organometallic Chemistry %I Sami Publishing Company %Z 2783-3623 %A Udgire, Somnath %A Gaikwad, Milind %A Patil, Prakash %D 2022 %\ 01/01/2022 %V 2 %N 1 %P 31-38 %! Bi(OTf)3 as a Highly Potent Catalyst for the Synthesis of Mannich Bases under Milder Conditions %K Bi(OTf)3 %K one-pot three-component %K greener %K Mannich reaction %R 10.22034/jaoc.2022.336265.1052 %X A simple, eco-friendly friendly and efficient procedure for the synthesis of Mannich Baseshas been developed via multi-component and one-pot reactions of various aldehydes with aniline, and acetophenone and catalytic amount of Bi(OTf)3 reagent in a DCM solvent.The Bi(OTf)3 acts as a highly potent catalyst ( 0.5 to 1 mol%) for a for the synthesis of Mannich base (1,3-diphenyl-3-(phenylamino)propan-1-one). This protocol is also compatible with a variety of hetero aldehyde carbonyl compounds in excellent yields. Thus, this practical method is developed as a notable medium for these derivatives via a multicomponent reaction. %U https://jaoc.samipubco.com/article_149115_b3d6a4de90a80ab99ac3349415a5681c.pdf