%0 Journal Article %T Docking and ADMET Study of Ar-Turmerone: Emerging Scaffold for Acetylcholine Esterase Inhibition and Antidiabetic Target %J Journal of Applied Organometallic Chemistry %I Sami Publishing Company %Z 2783-3623 %A Yusuf, Mohd. %A Pal, Sukhvinder %A Shahid, Mohammad %A Asif, Mohammad %A Khan, Shafat Ahmad %A Tyagi, Rakhi %D 2023 %\ 01/01/2023 %V 3 %N 1 %P 52-60 %! Docking and ADMET Study of Ar-Turmerone: Emerging Scaffold for Acetylcholine Esterase Inhibition and Antidiabetic Target %K In-Silico study %K Ar-turmerone %K Alzheimer’s disease %K Acetylcholine esterase %K Antidiabetic target %R 10.22034/jaoc.2023.384164.1070 %X In the present scenario of eco-preservation and eco-safe utilization, researchers globally have been attracted to the utilization of raw and sustainable products having significant therapeutic potential that allow safety, modality, and biological activeness with environmental compatibility. Ar-turmerone has various pharmacological actions, including antidepressant, antiepileptic, anti-dermatophyte, antivenom, anticancer, antiplatelet activity, etc. In the present work, we investigated Ar-Turmerone (Ar-Tume), one of the chief phytoconstituents present in Curcuma longa for human anticholinesterase (AChE) inhibitor (4PQE) and human salivary alpha-Amylase dimer (1XV8) hydrolase inhibitor as a natural product-based emerging scaffold. Our study reveals that the selected compound Ar-Tume showed remarked biological, ADMET profiling, and superior docking scores/negative binding energies (-7.9 against 4PQE and -6.7 against 1XV8) concerning the reference drugs, which attributed to the strong hydrogen-bonding interactions both towards both anti-Alzheimers and antidiabetic capabilities. %U https://jaoc.samipubco.com/article_167721_e6ccf0f43a8fa7c44903eae47ffe2682.pdf