Journal of Applied Organometallic Chemistry

Original Article

Analgesic Serotonin from Banana Fruit (Musa paradisiaca) on Serotonin 1 b (5-HT1b) Receptor Protein In Silico

Rahadian Zainul; Herland Satriawan; Dheo Shalsabilla Novel; Rismi Verawati; Amalia Putri Lubis; Vikash Jakhmola; Meksim Rebezov; Syafrizal Syafrizal; Shafique Ahmed; Mishra Lakshmi

Articles in Press, Accepted Manuscript, Available Online from 09 March 2024

https://doi.org/10.48309/jaoc.2024.443746.1166

Abstract

Serotonin analgesics from banana (Musa paradisiaca) fruit have been investigated to determine potential interactions with serotonin 1 b (5-HT1b) receptors at the molecular level. The ... Read More

Original Article

Quantum Computing Analysis of Naphthalene Compound: Electronic Structure, Optical, and Thermochemical Approaches using DFT and HF

Othman Abdulrahman Hamad; Rebaz Obaid Kareem; Yosif Hussein Azeez; Mehmet Hanifi Kebiroğlu; Rebaz Anwar Omer; Osama Ismail Haji Zebari

Articles in Press, Accepted Manuscript, Available Online from 19 March 2024

https://doi.org/10.48309/jaoc.2024.444132.1167

Abstract

The novelty of the work lies in the application of quantum computing analysis, specifically employing density functional theory (DFT) and Hartree-Fock (HF) techniques with various basis ... Read More

Original Article

Novel Mefenamic Acid Analogs Featuring 4-Thiazolidinone Moiety: Design, Synthesis, In Silico Modeling and Biological Evaluation

Arefeh Badrzadeh Shekarab; Niloofar Gharahchoulou; Seyed Sam Banisadr; Maryam Bayanati; Mohammad Mahboubi-Rabbani; Shima H.M.E Ketabforoosh; Homa Azizian; Ali Almasirad

Articles in Press, Accepted Manuscript, Available Online from 02 April 2024

https://doi.org/10.48309/jaoc.2024.440607.1162

Abstract

In this work, a novel series of mefenamic acid analogs were developed and synthesized with the goal of developing a lead chemical that has anti-inflammatory efficacy and avoids the ... Read More

Review Article

Appraisal of the Impact of Applying Organometallic Compounds in Cancer Therapy

Abdul Razak Mohamed Sikkander; Manoharan Meena; Hazarathaiah Yadav; Nitin Wahi; V. Vidya Lakshmi

Articles in Press, Accepted Manuscript, Available Online from 13 April 2024

https://doi.org/10.48309/jaoc.2024.433120.1154

Abstract

Chemotherapy for cancer frequently uses organometallic compounds containing platinum, such as oxaliplatin, carboplatin, and cisplatin. They are effective against rapidly dividing cancer ... Read More Chemotherapy for cancer frequently uses organometallic compounds containing platinum, such as oxaliplatin, carboplatin, and cisplatin. They are effective against rapidly dividing cancer cells because they form DNA adducts that cause DNA damage and cell death. They work against rapidly dividing cancer cells because of their mechanism of action, which involves the formation of covalent DNA adducts that obstruct DNA replication and transcription. It is true that cisplatin, carboplatin, and oxaliplatin three platinum containing organometallic compounds, are frequently utilized in cancer chemotherapy. These substances belong to a group of medications called platinum-based chemotherapeutics, and they have been used to treat a number of cancer types. Covalent DNA adducts are formed by oxaliplatin, carboplatin, and cisplatin to produce their anticancer effects. These substances contain platinum atoms that attach to purine bases in DNA to create intrastrain and interstream cross-links. These cross-links damage DNA and cause cell death by interfering with transcription and DNA replication. Platinum-containing compounds are extremely cytotoxic, especially to rapidly dividing cancer cells, because they can cause damage to DNA. The discovery and application of organometallic compounds containing platinum mark a critical advancement in the cancer treatment, and these compounds are still essential parts of chemotherapy regimens. Ongoing research endeavors to ascertain novel compounds based on platinum or substitute metals that exhibit enhanced effectiveness and diminished adverse reactions. These substances are well-known for their capacity to cause DNA damage in quickly proliferating cells, which can result in cell cycle arrest and eventual cell death. Although these conventional platinum drugs have demonstrated efficacy in treating a range of cancers, side effects and resistance development are linked to them. The dynamic field of research aims to improve the overall effectiveness and tolerability of chemotherapy by searching for new anticancer agents. New compounds with improved properties will probably continue to surface as our knowledge of cancer biology and drug development methods grows, which will help cancer treatment approaches to evolve.

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Journal of Applied Organometallic Chemistry

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Volume & Issue: Articles in Press

Analgesic Serotonin from Banana Fruit (Musa paradisiaca) on Serotonin 1 b (5-HT1b) Receptor Protein In Silico

Abstract

Quantum Computing Analysis of Naphthalene Compound: Electronic Structure, Optical, and Thermochemical Approaches using DFT and HF

Abstract

Novel Mefenamic Acid Analogs Featuring 4-Thiazolidinone Moiety: Design, Synthesis, In Silico Modeling and Biological Evaluation

Abstract

Appraisal of the Impact of Applying Organometallic Compounds in Cancer Therapy

Abstract