Original Article
Synthesis of (±)-Baclofen using Wittig Olefination–Claisen Rearrangement
1. Synthesis of (±)-Baclofen using Wittig Olefination–Claisen Rearrangement

Deekshaputra Ramrao Birhade; Rohit Gulab Shinde; Mahendra Nanduram Lokhande; Milind Dhondiba Nikalje

Volume 1, Issue 3 , Summer 2021, Pages 109-115

http://dx.doi.org/10.22034/jaoc.2021.284219.1018

Abstract
  Baclofen, a lipophilic derivative of GABA (gamma-Aminobutyric acid), which acts as an inhibitory neurotransmitter in CNS (central nervous system) was synthesized by Witting olefination-Claisen ...  Read More
Original Article
Pyridazine derivatives act as phosphodiesterase-III, IV, and V Inhibitors
2. Pyridazine derivatives act as phosphodiesterase-III, IV, and V Inhibitors

Saad Alghamdi; Mohammad Asif

Volume 1, Issue 3 , Summer 2021, Pages 116-124

http://dx.doi.org/10.22034/jaoc.2021.289851.1024

Abstract
  Pyridazine derivatives are significant bioactive molecules having wide range of biological activities. Phosphodiesterase (PDE) enzymes, particularly PDE-III, PDE-IV, and PDE-V are inhibited ...  Read More
Original Article
A comparison between density functional theory calculations and the additive schemes of polarizabilities of the Li-F-decorated BN cages
3. A comparison between density functional theory calculations and the additive schemes of polarizabilities of the Li-F-decorated BN cages

Maryam Anafcheh

Volume 1, Issue 3 , Summer 2021, Pages 125-131

http://dx.doi.org/10.22034/jaoc.2021.292384.1027

Abstract
  We have applied density functional theory calculations to study the polarizabilities of the LiF decorated B12N12 cages (B12N12LinFn derivatives, n=1-12). The mean polarizability of ...  Read More
Original Article
Glycine: An Efficient Catalyst for the Synthesis of Tetra-Substituted Imidazole Derivatives in Aqueous Medium
4. Glycine: An Efficient Catalyst for the Synthesis of Tetra-Substituted Imidazole Derivatives in Aqueous Medium

Jitendra Bhausaheb Gujar; Balaji Shahaji Londhe; Raghunath Narayan Zambare; Rajesh Janardan Kavade; Murlidhar Shridhar Shingare

Volume 1, Issue 3 , Summer 2021, Pages 132-140

http://dx.doi.org/10.22034/jaoc.2021.294427.1030

Abstract
  A single-pot, tandem reaction in which cyclization through condensation of 1, 2-diphenylethane-1, 2-dione, benzaldehyde, aniline, and ammonium acetate has been accomplished by orthodox ...  Read More
Mini-Review Article
New advances on Modulating nanomagnetic cores as the MRI-monitored drug release in cancer
5. New advances on Modulating nanomagnetic cores as the MRI-monitored drug release in cancer

Fatemeh Mohajer; Ghodsi Mohammadi Ziarani; A. R. Badiei

Volume 1, Issue 3 , Summer 2021, Pages 141-145

http://dx.doi.org/10.22034/jaoc.2021.301405.1032

Abstract
  Multifunctional magnetic nanostructures were considered by different functional organic groups to use as a drug delivery arrangement in cancer therapy. The modulating nonmagnetic core-shell, ...  Read More
Original Article
Quantum chemical and molecular docking studies of some phenothiazine derivatives
6. Quantum chemical and molecular docking studies of some phenothiazine derivatives

G. Venkatesh; Y. Sheena mary; Y. Shymamary; Vennila Palanisamy; M. Govindaraju

Volume 1, Issue 3 , Summer 2021, Pages 146-155

http://dx.doi.org/10.22034/jaoc.2021.303059.1033

Abstract
  Phenothiazines are synthetic antipsychotics with a wide range of biological effects. Their properties are determined by the structure and variety of substituents in the heterocyclic ...  Read More