Original Article
Synthesis of (±)-Baclofen using Wittig Olefination–Claisen Rearrangement
Synthesis of (±)-Baclofen using Wittig Olefination–Claisen Rearrangement

Deekshaputra Ramrao Birhade; Rohit Gulab Shinde; Mahendra Nanduram Lokhande; Milind Dhondiba Nikalje

Volume 1, Issue 3 , July 2021, Pages 109-115

https://doi.org/10.22034/jaoc.2021.284219.1018

Abstract
  Baclofen, a lipophilic derivative of GABA (gamma-Aminobutyric acid), which acts as an inhibitory neurotransmitter in CNS (central nervous system) was synthesized by Witting olefination-Claisen ...  Read More
Original Article
Pyridazine derivatives act as phosphodiesterase-III, IV, and V Inhibitors
Pyridazine derivatives act as phosphodiesterase-III, IV, and V Inhibitors

Saad Alghamdi; Mohammad Asif

Volume 1, Issue 3 , July 2021, Pages 116-124

https://doi.org/10.22034/jaoc.2021.289851.1024

Abstract
  Pyridazine derivatives are significant bioactive molecules having wide range of biological activities. Phosphodiesterase (PDE) enzymes, particularly PDE-III, PDE-IV, and PDE-V are inhibited ...  Read More
Original Article
A comparison between density functional theory calculations and the additive schemes of polarizabilities of the Li-F-decorated BN cages
A comparison between density functional theory calculations and the additive schemes of polarizabilities of the Li-F-decorated BN cages

Maryam Anafcheh

Volume 1, Issue 3 , July 2021, Pages 125-133

https://doi.org/10.22034/jaoc.2021.292384.1027

Abstract
  We have applied density functional theory calculations to study the polarizabilities of the LiF decorated B12N12 cages (B12N12LinFn derivatives, n=1-12). The mean polarizability of ...  Read More
Original Article
Glycine: An Efficient Catalyst for the Synthesis of Tetra-Substituted Imidazole Derivatives in Aqueous Medium
Glycine: An Efficient Catalyst for the Synthesis of Tetra-Substituted Imidazole Derivatives in Aqueous Medium

Jitendra Bhausaheb Gujar; Balaji Shahaji Londhe; Raghunath Narayan Zambare; Rajesh Janardan Kavade; Murlidhar Shridhar Shingare

Volume 1, Issue 3 , July 2021, Pages 134-142

https://doi.org/10.22034/jaoc.2021.294427.1030

Abstract
  A single-pot, tandem reaction in which cyclization through condensation of 1, 2-diphenylethane-1, 2-dione, benzaldehyde, aniline, and ammonium acetate has been accomplished by orthodox ...  Read More
Mini-Review Article
New Advances on Modulating Nanomagnetic Cores as the MRI-Monitored Drug Release in Cancer
New Advances on Modulating Nanomagnetic Cores as the MRI-Monitored Drug Release in Cancer

Fatemeh Mohajer; Ghodsi Mohammadi Ziarani; Alireza Badiei

Volume 1, Issue 3 , July 2021, Pages 143-147

https://doi.org/10.22034/jaoc.2021.301405.1032

Abstract
  Multifunctional magnetic nanostructures were considered by different functional organic groups to use as a drug delivery arrangement in cancer therapy. The modulating nonmagnetic core-shell, ...  Read More
Original Article
Quantum Chemical Calculations and Molecular Docking Studies of Some Phenothiazine Derivatives
Quantum Chemical Calculations and Molecular Docking Studies of Some Phenothiazine Derivatives

Ganesan Venkatesh; Yohannan Sheena mary; Y. Shymamary; Vennila Palanisamy; M. Govindaraju

Volume 1, Issue 3 , July 2021, Pages 148-158

https://doi.org/10.22034/jaoc.2021.303059.1033

Abstract
  Phenothiazines are synthetic antipsychotics with a wide range of biological effects. Their properties are determined by the structure and variety of substituents in the heterocyclic ...  Read More