@article { author = {Dhange, Maroti and Patwari, Shivaji and Kaminwar, Nitishkumar and Madje, Balaji and P. Rajani, Dhanji and Pokalwar, Rajkumar}, title = {Antituberculosis Activity, Synthesis of 3-((1H-Benzo[d]imidazol-2-ylthio)methyl)-2-chloroquinoline Derivatives Using Copper Nanoparticles Grafted on Carbon Microspheres}, journal = {Journal of Applied Organometallic Chemistry}, volume = {3}, number = {1}, pages = {39-51}, year = {2023}, publisher = {Sami Publishing Company}, issn = {2783-3623}, eissn = {2783-1272}, doi = {10.22034/jaoc.2023.359825.1061}, abstract = {The copper nanoparticles grafted on carbon microsphere (Cu-NP/C) catalyst was used to create a convenient and efficient synthesis of 3-(1H-benzo(d)imidazole-2-yithio) methyl-2-chloroquinoline (4a-f) from 2-Chloroquinoline-3-carbaldehyde (1a-f) and 1H-benzo[d]imidazole-2-thiol (Scheme-1, Table-2). The synthesis was placed under mild reaction conditions, resulting in a excellent yield (92-97%, Table-2) of the appropriate compounds. The prepared compounds were characterized by H1NMR, IR, and Mass spectroscopy. These synthesized compounds were studied for antituberculosis activities (Table-3, 4a-f) against standard drug isoniazid and rifampicin and show moderate activity. To explain the experimentally discovered affinity for 3-((1H-benzo[d]imidazol-2-ylthio)methyl)-2-chloroquinoline derivatives, molecular docking studies were conducted. A molecular docking study reveals the 4e and 4f derivatives of 3-((1H-benzo[d]imidazol-2-ylthio)methyl)-2-chloroquinoline to be the most active ones.}, keywords = {3-(1H-benzo(d)imidazole-2-yithio)methyl-2-chloroquinoline,2-chloroquinoline-3-carbaldehyde,Antituberculosis Activity,Molecular docking,1H-benzo[d]imidazole-2-thiol,Copper Nanoparticles Grafted on Carbon Microspheres}, url = {https://jaoc.samipubco.com/article_158629.html}, eprint = {https://jaoc.samipubco.com/article_158629_ccaf64422a3bdc4db8d774e9926dda70.pdf} }