Journal of Applied Organometallic Chemistry

Analgesic Serotonin from Banana Fruit (Musa paradisiaca) on Serotonin 1 b (5-HT1b) Receptor Protein In Silico

Rahadian Zainul; Herland Satriawan; Dheo Shalsabilla Novel; Rismi Verawati; Amalia Putri Lubis; Vikash Jakhmola; Meksim Rebezov; Syafrizal Syafrizal; Shafique Ahmed; Mishra Lakshmi

Articles in Press, Accepted Manuscript, Available Online from 09 March 2024

https://doi.org/10.48309/jaoc.2024.443746.1166

Abstract

Serotonin analgesics from banana (Musa paradisiaca) fruit have been investigated to determine potential interactions with serotonin 1 b (5-HT1b) receptors at the molecular level. The ... Read More

Appraisal of the Impact of Applying Organometallic Compounds in Cancer Therapy

Abdul Razak Mohamed Sikkander; Manoharan Meena; Hazarathaiah Yadav; Nitin Wahi; V. Vidya Lakshmi

Articles in Press, Accepted Manuscript, Available Online from 13 April 2024

https://doi.org/10.48309/jaoc.2024.433120.1154

Abstract

Chemotherapy for cancer frequently uses organometallic compounds containing platinum, such as oxaliplatin, carboplatin, and cisplatin. They are effective against rapidly dividing cancer ... Read More Chemotherapy for cancer frequently uses organometallic compounds containing platinum, such as oxaliplatin, carboplatin, and cisplatin. They are effective against rapidly dividing cancer cells because they form DNA adducts that cause DNA damage and cell death. They work against rapidly dividing cancer cells because of their mechanism of action, which involves the formation of covalent DNA adducts that obstruct DNA replication and transcription. It is true that cisplatin, carboplatin, and oxaliplatin three platinum containing organometallic compounds, are frequently utilized in cancer chemotherapy. These substances belong to a group of medications called platinum-based chemotherapeutics, and they have been used to treat a number of cancer types. Covalent DNA adducts are formed by oxaliplatin, carboplatin, and cisplatin to produce their anticancer effects. These substances contain platinum atoms that attach to purine bases in DNA to create intrastrain and interstream cross-links. These cross-links damage DNA and cause cell death by interfering with transcription and DNA replication. Platinum-containing compounds are extremely cytotoxic, especially to rapidly dividing cancer cells, because they can cause damage to DNA. The discovery and application of organometallic compounds containing platinum mark a critical advancement in the cancer treatment, and these compounds are still essential parts of chemotherapy regimens. Ongoing research endeavors to ascertain novel compounds based on platinum or substitute metals that exhibit enhanced effectiveness and diminished adverse reactions. These substances are well-known for their capacity to cause DNA damage in quickly proliferating cells, which can result in cell cycle arrest and eventual cell death. Although these conventional platinum drugs have demonstrated efficacy in treating a range of cancers, side effects and resistance development are linked to them. The dynamic field of research aims to improve the overall effectiveness and tolerability of chemotherapy by searching for new anticancer agents. New compounds with improved properties will probably continue to surface as our knowledge of cancer biology and drug development methods grows, which will help cancer treatment approaches to evolve.

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A Short Review of Past, Present, and Future of Metallocene and Its Derivatives as an Effective Therapeutic Agent

Saroj Sharma

Volume 3, Issue 2 , June 2023, , Pages 142-155

https://doi.org/10.22034/jaoc.2023.398871.1083

Abstract

This review provides a concise overview of the past, present, and future applications of ferrocene and its derivatives in drug discovery. Ferrocene-based compounds have shown promise ... Read More

Quantum Chemical Calculations and Molecular Docking Studies of Some Phenothiazine Derivatives

Ganesan Venkatesh; Yohannan Sheena mary; Y. Shymamary; Vennila Palanisamy; M. Govindaraju

Volume 1, Issue 3 , July 2021, , Pages 148-158

https://doi.org/10.22034/jaoc.2021.303059.1033

Abstract

Phenothiazines are synthetic antipsychotics with a wide range of biological effects. Their properties are determined by the structure and variety of substituents in the heterocyclic ... Read More

Journal of Applied Organometallic Chemistry

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Volume 4 (2024)

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Main Subjects = Pharmaceutical Chemistry

Analgesic Serotonin from Banana Fruit (Musa paradisiaca) on Serotonin 1 b (5-HT1b) Receptor Protein In Silico

Abstract

Appraisal of the Impact of Applying Organometallic Compounds in Cancer Therapy

Abstract

A Short Review of Past, Present, and Future of Metallocene and Its Derivatives as an Effective Therapeutic Agent

Abstract

Quantum Chemical Calculations and Molecular Docking Studies of Some Phenothiazine Derivatives

Abstract