Journal of Applied Organometallic Chemistry

Original Article

Analgesic Serotonin from Banana Fruit (Musa paradisiaca) on Serotonin 1 b (5-HT1b) Receptor Protein In Silico

Rahadian Zainul; Herland Satriawan; Dheo Shalsabilla Novel; Rismi Verawati; Amalia Putri Lubis; Vikash Jakhmola; Meksim Rebezov; Syafrizal Syafrizal; Shafique Ahmed; Mishra Lakshmi

Volume 4, Issue 2 , May 2024, Pages 88-99

https://doi.org/10.48309/jaoc.2024.443746.1166

Abstract

Serotonin analgesics from banana (Musa paradisiaca) fruit have been investigated to determine potential interactions with serotonin 1 b (5-HT1b) receptors at the molecular level. The ... Read More

Original Article

Quantum Computing Analysis of Naphthalene Compound: Electronic Structure, Optical, and Thermochemical Approaches using DFT and HF

Othman Abdulrahman Hamad; Rebaz Obaid Kareem; Yosif Hussein Azeez; Mehmet Hanifi Kebiroğlu; Rebaz Anwar Omer; Osama Ismail Haji Zebari

Volume 4, Issue 2 , May 2024, Pages 100-118

https://doi.org/10.48309/jaoc.2024.444132.1167

Abstract

The novelty of the work lies in the application of quantum computing analysis, specifically employing density functional theory (DFT) and Hartree-Fock (HF) techniques with various basis ... Read More

Original Article

Novel Mefenamic Acid Analogs Featuring 4-Thiazolidinone Moiety: Design, Synthesis, In Silico Modeling and Biological Evaluation

Arefeh Badrzadeh Shekarab; Niloofar Gharahchoulou; Seyed Sam Banisadr; Maryam Bayanati; Mohammad Mahboubi-Rabbani; Shima H.M.E Ketabforoosh; Homa Azizian; Ali Almasirad

Volume 4, Issue 2 , May 2024, Pages 119-134

https://doi.org/10.48309/jaoc.2024.440607.1162

Abstract

In this work, a novel series of mefenamic acid analogs were developed and synthesized with the goal of developing a lead chemical that has anti-inflammatory efficacy and avoids the ... Read More

Original Article

A Cheaper and Greener Approach for the Synthesis of Highly Pure Silicon Carbide Composites Using Coffee Husk Wastes

Samuel N. Ndung’u; Esther w. Nthiga; Ruth N. Wanjau; Anthony M. Ndiritu

Volume 4, Issue 2 , May 2024, Pages 135-144

https://doi.org/10.48309/jaoc.2024.446126.1171

Abstract

The extensive use of silicon carbide in many fields such as in abrasives, structural materials, refractories, electronic components, and nuclear reactors amongst others demands for ... Read More

Review Article

Appraisal of the Impact of Applying Organometallic Compounds in Cancer Therapy

Abdul Razak Mohamed Sikkander; Manoharan Meena; Hazarathaiah Yadav; Nitin Wahi; V. Vidya Lakshmi

Volume 4, Issue 2 , May 2024, Pages 145-166

https://doi.org/10.48309/jaoc.2024.433120.1154

Abstract

Chemotherapy for cancer frequently uses organometallic compounds containing platinum, such as oxaliplatin, carboplatin, and cisplatin. They are effective against rapidly dividing cancer ... Read More Chemotherapy for cancer frequently uses organometallic compounds containing platinum, such as oxaliplatin, carboplatin, and cisplatin. They are effective against rapidly dividing cancer cells because they form DNA adducts that cause DNA damage and cell death. They work against rapidly dividing cancer cells because of their mechanism of action, which involves the formation of covalent DNA adducts that obstruct DNA replication and transcription. It is true that cisplatin, carboplatin, and oxaliplatin three platinum containing organometallic compounds, are frequently utilized in cancer chemotherapy. These substances belong to a group of medications called platinum-based chemotherapeutics, and they have been used to treat a number of cancer types. Covalent DNA adducts are formed by oxaliplatin, carboplatin, and cisplatin to produce their anticancer effects. These substances contain platinum atoms that attach to purine bases in DNA to create intrastrain and interstream cross-links. These cross-links damage DNA and cause cell death by interfering with transcription and DNA replication. Platinum-containing compounds are extremely cytotoxic, especially to rapidly dividing cancer cells, because they can cause damage to DNA. The discovery and application of organometallic compounds containing platinum mark a critical advancement in the cancer treatment, and these compounds are still essential parts of chemotherapy regimens. Ongoing research endeavors to ascertain novel compounds based on platinum or substitute metals that exhibit enhanced effectiveness and diminished adverse reactions. These substances are well-known for their capacity to cause DNA damage in quickly proliferating cells, which can result in cell cycle arrest and eventual cell death. Although these conventional platinum drugs have demonstrated efficacy in treating a range of cancers, side effects and resistance development are linked to them. The dynamic field of research aims to improve the overall effectiveness and tolerability of chemotherapy by searching for new anticancer agents. New compounds with improved properties will probably continue to surface as our knowledge of cancer biology and drug development methods grows, which will help cancer treatment approaches to evolve.

Original Article

Efficient Synthesis of Benzimidazole Incorporated by PFPAT Catalyst at Room Temperature

Sunil Baburao Jagtap; Abhijeet Sanjayrao Patki; Dyanoba Baburao Muley

Volume 4, Issue 2 , May 2024, Pages 167-177

https://doi.org/10.48309/jaoc.2024.444613.1168

Abstract

In the present protocol, we have developed a new and competent route for the development of benzimidazole staring with the aromatic diamine with differently substituted benzaldehyde ... Read More

Anti-microbial evaluation, Experimental and Theoretical Insights into Molecular Structure, Electronic Properties, and Chemical Reactivity of (E)-2-((1H-indol-3-yl)methylene)-2,3-dihydro-1H-inden-1-one

Rahul Shinde; Vishnu A Adole

Volume 1, Issue 2 , April 2021, , Pages 48-58

https://doi.org/10.22034/jaoc.2021.278742.1011

Abstract

The present investigation describes antimicrobial, computational, study of (E)-2-((1H-indol-3-yl)methylene)-2,3-dihydro-1H-inden-1-one (IMDHI) molecule. The spectroscopic characterization ... Read More

Iodine‐DMSO Catalyzed aromatization of Polysubstituted Cyclohexanone derivatives; An efficient methods for the synthesis of polyfunctionized Biaryls derivatives

Sunil V. Gaikwad; Milind V. Gaikwad; Pradeep D. Lokhande

Volume 1, Issue 1 , February 2021, , Pages 1-8

https://doi.org/10.22034/jaoc.2021.128538

Abstract

AbstractWe have developed a simple method for the regioselective aromatization of Polysubstituted Cyclohexanone derivatives in the presence of iodine (25 mol %), Pd/C (10Mol%) in dimethyl ... Read More

High-yield Production of Amorphous Carbon via Ball Milling of Graphite and Prediction of Its Crystallite Size through ANN

Seyed Oveis Mirabootalebi; Gholam Hosien Akbari Fakhrabadi; Reza Mirahmadi Babaheydari

Volume 1, Issue 2 , April 2021, , Pages 76-85

https://doi.org/10.22034/jaoc.2021.288020.1021

Abstract

< p>One of the main methods for the synthesis of amorphous and nanostructured carbon is the mechanical milling of graphite. However, calculation and anticipation of the amorphous ... Read More

A Brief Review of Recent Furfural Production from Lignocellulosic Biomass: State of the Art of Processes, Technologies, and Optimization

Md Riajul Islam Sardar; Fardaush Hasan; Md. Jone Alam; Imam Hossain Nadim; Md. Mahmud

Volume 3, Issue 2 , June 2023, , Pages 108-122

https://doi.org/10.22034/jaoc.2023.394685.1078

Abstract

Furfural, an environmentally friendly alternative to petroleum-derived products, has gained significant attention as a versatile and sustainable chemical. This review article presents ... Read More

Computational Chemistry Approach for the Investigation of Structural, Electronic, Chemical and Quantum Chemical Facets of Twelve Biginelli Adducts

Vishnu A Adole

Volume 1, Issue 1 , February 2021, , Pages 29-40

https://doi.org/10.22034/jaoc.2021.278598.1009

Abstract

The rising concerns about the Biginelli reaction are mainly attributable to the therapeutic and pharmacological features of Biginelli adducts, especially dihydropyrimidinones (DHPMs). ... Read More

Figure and Facts
Google Scholar h-index	14
Google Scholar i10-index	22
Google Scholar Citation	528
WOS Citation	244
Issue per year	4
No. of volumes	4
No. of Issues	14
Number of Articles	84
Number of Submissions	197
Rejected Submissions	105
Acceptance rate	36
Accept Date (Days)	39
Review papers	0
No. of contributors	291
Article view	29,815
View Per Article	354.94
PDF download	14,558
PDF Download Per Article	173.31
No. of reviewers	7462
Contributing countries	3
No. of databases	9

Volume 4 (2024)

Volume 3 (2023)

Volume 2 (2022)

Volume 1 (2021)

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